3
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37424 |
CAY10781
CAY10781 |
Others | Others |
CAY10781 是一种神经纤毛蛋白-1 (NRP-1) 和 VEGF-A.1 之间蛋白质-蛋白质相互作用的抑制剂。当使用浓度为 12.5 μM 时,它可抑制 43% 的相互作用。 当以相同浓度使用时,CAY10781 还抑制 VEGF-A 诱导的儿茶酚胺 A 分化 (CAD) 细胞中 VEGFR2 的磷酸化。 | |||
T63035 |
Izilendustat hydrochloride
|
||
Izilendustat (hydrochloride) 是一种脯氨酰羟化酶 (prolyl hydroxylase) 的有效抑制剂,能够稳定缺氧诱导因子-1 α (HIF-1α) 和缺氧诱导因子-2 (HIF-2)。Izilendustat (hydrochloride) 具有潜力进行 HIF-1α 相关疾病的研究(包括外周血管疾病(PVD)、心力衰竭、冠状动脉疾病(CAD)、缺血、贫血、结肠炎和其他炎症性肠病)。 | |||
T68297 |
Dilmapimod tosylate
|
||
Dilmapimod tosylate is a potent p38 mitogen-activated protein kinase (MAPK) inhibitor. It was investigated for its anti-inflammatory effect in non-head injury trauma patients at risk for developing acute respiratory distress syndrome. IL-1β was identified as a gene regulated by dilmapimod that could influence c-reactive protein levels. Dilmapimod had been in phase III clinical trials by GlaxoSmithKline for the treatment of rheumatoid arthritis, neuropathic pain, coronary artery disease (CAD) and... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00483 |
DFF45 Protein, Human, Recombinant (His)
DNA Fragmentation Factor Subunit Alpha,DFF45,H13,ICAD |
Human | E. coli |
DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF), which in turn triggers DNA fragmentation as well as chromatin condensation during apoptosis. A reduced level of DFFA detected in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression. |